Terconazole

A to Z Drug Facts

 Action May alter permeability of fungus cell membrane, allowing leakage of essential intracellular components.

 Indications Local treatment of vulvovaginal candidiasis.

 Contraindications Standard considerations.

 Route/Dosage

ADULTS: Intravaginal 1 suppository at bedtime for 3 days or 1 applicatorful of 0.4% cream at bedtime for 7 days or 1 applicatorful of 0.8% cream for 3 days.

 Interactions None well documented.

 Lab Test Interferences None well documented.

 Adverse Reactions

CNS: Headache. GI: Abdominal pain. GU: Dysmenorrhea; genitalia pain; vulvovaginal burning; itching; irritation; burning. OTHER: Body pain; fever; chills.

 Precautions

Pregnancy: Category C; avoid during first trimester due to absorption possibility. Lactation: Undetermined. Children: Safety and efficacy not established. Recurrent infections: May indicate underlying medical cause, including diabetes or HIV infection.

 Administration/Storage

• Insert applicator high in vagina.
• Store at room temperature.

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Ask patient about local reactions. If reactions are severe or symptoms of infection persist or worsen, notify physician.

 Patient/Family Education

• Instruct patient to complete full course of therapy. This medication must be used continuously even through menses.
• Alert patient to potential side effects of vulvovaginal itching or burning, head or body aches. Advise patient to discontinue medication and notify physician if irritation occurs.
• Instruct patient to insert applicator high into vagina.
• Wash hands before and after application. Also, maintain external clean genitalia but avoid use of douches or other vaginal otc products while using the medication.
• Advise patient to wash applicator with mild soap and rinse thoroughly.
• Caution patient to refrain from sexual intercourse during course of therapy in order to help to prevent reinfection.
• Advise patient that sanitary napkin or minipad may be used to prevent stains on clothing.
• Instruct patient to consult with physician if infection recurs. Diabetes, AIDS and chronic antibiotic or steroid therapy place patient at increased risk for recurrent infection.
• Explain that ingredients in product may interact with latex and weaken latex condoms and diaphragms. Advise patient to avoid use of these forms of birth control for 72 hr after application of medication.

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Copyright © 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts